The Protocol to Raise It


the25percent Newsletter

What actually works for healthspan.

April 02, 2026

Last time, I shared my VO2max number: 33.84. Below the 50th percentile for my age. Poor on my Garmin. Now the question that matters: how do I raise it?

The answer has been studied for decades. And one protocol has the strongest evidence behind it.


The Norwegian 4x4

Four intervals. Four minutes each. At 90-95% of your max heart rate. Three minutes of active recovery between intervals at around 70% HRmax. Ten minutes of warm-up, a few minutes of cool-down. Total session: about 40 minutes.

That’s the protocol.

In 2007, Helgerud and colleagues at the Norwegian University of Science and Technology tested four different training methods head-to-head. Same total work output across all groups. Eight weeks. Three sessions per week.

The results:

  • 4x4 intervals: +7.2% VO2max
  • 15/15 intervals (15 seconds on, 15 seconds off): +5.5%
  • Lactate threshold training (85% HRmax): +2.0%
  • Long slow distance (70% HRmax, 45 minutes): -0.6%

Read that last one again. The long slow distance group went backwards. Same total work as the 4x4 group. Radically different results.

Then there’s the Generation 100 study: 1,567 Norwegian adults aged 70-77, followed for five years. The group doing 4x4 intervals had a 3.0% mortality rate. The moderate-intensity group: 5.9%. The difference didn’t reach statistical significance, but the trend is hard to ignore.

The 4x4 works. It’s one of the most studied, most repeatable interval formats in the literature.


The principle matters more than the format

Here’s what I want to be clear about: the 4x4 is one of the most studied protocols. But it’s not the only one that works.

The principle behind it is what drives the adaptation: hit 90-95% of your max heart rate, sustain it long enough, recover, repeat. Whether you do that on a Wattbike, a treadmill at incline, a rowing machine, or running hills, your cardiovascular system doesn’t care about the label on the workout.

Helgerud’s own 15/15 group improved VO2max by 5.5%. A different format, and statistically not significantly different from 4x4. Both high-intensity protocols crushed the moderate and low-intensity groups.

Your Zwift workout, your gym’s stairmaster, a hill sprint session: if you’re hitting the right intensity and recovering between efforts, you’re getting the adaptation.

I’ve been doing structured intervals on the bike — different plans, different formats. Not the 4x4 specifically. But the same principle applies: push the intensity, recover, repeat.

The 4x4 is what I’m building toward as I shift to more interval-focused training. But I’m not going to pretend I started there.

Fun matters too. Variance keeps you on the bike. And consistency is what actually produces results over months and years.


How it fits into your week

The polarized training model: roughly 80% of your training at low intensity (Zone 2), 20% at high intensity.

In practice, that looks like:

  • 3–4 Zone 2 sessions (45-60+ minutes each, at least 150+ minutes)
  • 1–2 interval sessions per week

Two interval sessions per week means about 32 minutes of work at high intensity. That’s it. The rest is Zone 2.

Allow 48-72 hours between interval sessions. Your cardiovascular system needs recovery time to adapt.

And a critical point: don’t replace Zone 2 with intervals. They serve different purposes. Zone 2 builds the base. Intervals push the ceiling. You need both.


Start here

If you’re currently only doing Zone 2, add one interval session per week.

  • Week 1-2: One session. Start shorter if needed: 3x4 instead of 4x4, or a 30-minute structured workout from whatever app you use.
  • Week 3-4: Full session length, still once per week.
  • Week 5+: Add a second session if your recovery allows it.

The intervals should feel hard. If they don’t, you’re not in the right zone. At 90-95% HRmax, holding a conversation is not possible. That’s the point.

One common misconception: a hard spin class or boutique cycling session that keeps you at 80-85% HRmax for 45 minutes is neither Zone 2 nor VO2max training. It’s the grey zone between them — too hard for aerobic base building, not hard enough to push your ceiling. More on this next time.


What’s next

Zone 2 builds the base. VO2max training pushes the ceiling.

Next time: why intensity has a multiplier effect that most people underestimate, and what the research says about vigorous exercise and longevity.


From the archive

New here? Start with The Beginner’s Guide to Longevity Training.


One ask

What interval protocol are you using? Or what’s stopping you from starting? Reply and tell me.

Alessandro

600 1st Ave, Ste 330 PMB 92768, Seattle, WA 98104-2246
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A science-backed longevity training app for enthusiasts ready to invest seriously in their healthspan. After over 15 years as a UX consultant, I realized that most fitness advice optimizes you for ages 25 to 30, not 60 and above. Now I'm building the demanding but achievable protocol I wish existed, backed by the latest longevity science. Join me for evidence-based insights on training, healthspan, habit formation, and the reality of bootstrapping a health-tech startup.

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